The train accident took lives of at least 4 people and injured more than 26.
The crash took place late Wednesday night in the city of Pardubice.
The dead were not immediately identified, however, the drivers in both engines survived.
The corridor in Pardubice, where the trains collided, is vital for Czech Railways.
PM Petr Fiala called the crash a big tragedy and offered his condolences
Police said they were investigating possible human negligence.
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