It turned out to be a dismal day for Saina and Prannoy, who had clinched the National championship titles at Nagpur earlier this month.
Saina Nehwal, who has been performing exceedingly well from last few weeks, failed to stick to her good form and slumped to a shocking 18-21, 11-21 defeat in second round.
world no. 2 Sindhu was made to work hard by her Japanese opponent Sato as the Indian toiled hard for 59 minutes on the court to get the better of Sato 24-22 23-21.
The ace shuttler will now square off with fifth-seed Akane Yamaguchi of Japan for a place in the quarter-finals of the women's singles event of China Open.
Kidambi Srikanth, who clinched four titles and reached five finals in this season, will be taking a break this week to nurse a muscle strain.
The former world number one, Saina got the better of Sindhu, the Olympic and World Championship silver medallist 21-17, 27-25 in a pulsating summit clash that lasted 54 minutes.
In the men's singles event, India's top male shuttler Srikanth dispatched Shubham Prajapati in straight games 21-17 23-21 to advance to the next round.
Sindhu dumped Japan's Sayaka Takahashi 21-14 21-13 to set up a revenge match against China's Chen Yufei in the quarterfinals of French Open Super Series.
London Games bronze-medallist Saina staved off a spirited challenge from Denmark's rising shuttler Line Hjmark Kjaersfeldt 21-14 11-21 21-10 and is likely to clash with Japan's Akane Yamaguchi in a revenge match.
Srikanth, who decimated Korean veteran Lee Hyun II in a lop-sided final on Sunday at Odense, will open his campaign against England's Rajiv Ouseph, who had reached the quarterfinals at Denmark Open last week.
Saina Nehwal has made a successful comeback from injury with a World Championship bronze medal while Kidambi Srikanth has now won three Super series titles in one season.
Exhausted after being forced to play a late night match on Thursday due to a power failure at the stadium, Saina Nehwal lost 10-21, 13-21 to Akane Yamaguchi of Japan.
Former world number one Saina knocked Olympic champion Carolina Marin out of Denmark Open on Wednesday in the first round to avenge her Japan Open second-round loss to the Spaniard.
Title-contender Sindhu failed to break the rhythm of World No 10 Chen Yufei to go down fighting 17-21 21-23 in a 43-minute opening round match on Wednesday.
Indians Kidambi Srikanth and H S Prannoy made positive starts to the tournament but B Sai Praneeth crashed out in the opening round of men's singles.
Defending champions Chennai Smashers retained Olympic silver medallist and their star shuttler PV Sindhu for a whopping price of Rs 48.75 lakhs in PBL auction on Monday.
Chinese Taipei's Tai Tzu Ying retained her top spot. London Olympics bronze winner Saina Nehwal was static at the 12th spot.
Saina will take on reigning Olympic champion Carolina Marin in the next round where the Indian has a 4-3 record against the Spaniard, having lost thrice in the last four meetings.
Kashyap first got past Denmark's Emil Holst 21-15, 21-14 but lost to Japanese Yu Igarashi 11-21, 21-18, 14-21 in an hour and five minutes in the second qualifying match.
Sindhu avenged her World Championship heart-break by beating Nozomi Okuhara in a pulsating summit clash of Korea Open to claim her second super series title of the season.
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