Chasing his 100th career title after winning the Swiss Indoors last Sunday, the 20-time Grand Slam champion was hardly troubled.
If Federer wins the ongoing Paris Masters it will be his career's 100th tournament win.
Also, Roger Federer advanced to the third round after big-serving Milos Raonic retired with a right elbow injury.
The U.S. Open champion won four of the last five tournaments he has entered, including Wimbledon, the U.S. Open and most recently the Shanghai Masters.
A ninth title at Federer's hometown event in Basel, where he was once a ball boy, matched the nine he won at the Halle grass-court event in Germany.
At the Australian Open and the French Open, players still have to win by two games in the final set in singles matches.
Serbia's Novak Djokovic climbed one spot up to the second, after claiming the Shanghai Masters title for the fourth time in a row on Sunday.
Roger Federer reached the semi-finals on Friday by beating eighth-seeded Kei Nishikori 6-4, 7-6 (4). His first two matches both went three sets.
Federer, the defending champion, beat Daniil Medvedev 6-4, 4-6, 6-4 in the second round despite being broken late in the second set.
Roger Federer earlier put Team Europe ahead by saving three match points for a 6-7, 7-6, (10-7) victory over John Isner.
Federer and Djokovic took the first set 7-6 in a tiebreaker, but Sock and Anderson won the second set 6-3 and then captured the deciding tiebreaker 10-6.
Djokovic moved a step closer to a third championship at Flushing Meadows and 14th Grand Slam title overall by eliminating John Millman, who conquered Roger Federer in quarterfinals of US Open 2018.
Roger Federer suffered a shocking 3-6, 7-5, 7-6 (7), 7-6 (3) defeat to 55th-ranked John Millman of Australia in the fourth round of the 2018 US Open.
The No. 2-seeded Federer moved into the fourth round at Flushing Meadows for the 17th consecutive appearance. He's won five titles at the U.S Open, although the last arrived a decade ago.
Federer was crisp in a 7-5, 6-4, 6-4 win over Benoit Paire in and made it 18 of 18 lifetime in the second round of the U.S. Open.
For years, actually, Federer has dealt with questions about when he might retire. In part, that's because elite tennis players often used to become not-so-elite by the time they passed the age of 30.
Federer saved the first eight break points he faced before finally faltering by pushing a forehand long on the ninth.
The Swiss maestro had won five titles in a row in Flushing Meadows and was a game away from a sixth in 2009 when Juan Martin del Potro pulled out a fourth-set tiebreaker, then won the fifth set.
A six-player team from Europe will face a team of players from the rest of the world in the second year of the competition on Sept. 21-23.
Djokovic finally mastered the one tournament that's eluded him, beating nemesis Roger Federer 6-4, 6-4 on Sunday.
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