A day after saving two match points at the Madrid Open, Federer squandered two match points himself in the quarterfinals against Dominic Thiem on Friday, losing 3-6, 7-6 (11), 6-4.
Roger Federer eased past John Isner in the Miami Open final 6-1, 6-4 to win his 101st career title on Sunday.
There still has not been a repeat champion this year among the men or women.
Roger Federer beat Denis Shapovalov 6-2, 6-4 while John Isner got the better of Felix Auger-Aliassime, 7-6, 7-6 in the semi-finals of Miami Open.
The day's winners were Federer, Shapovalov, Barty, Pliskova and the rain.
Dominic Thiem defeated Roger Federer 3-6, 6-3, 7-5 in the final while Canadian teenager Bianca Andreescu upset Angelique Kerber 6-4, 3-6, 6-4 to win the women's title at Indian Wells.
A somber Nadal announced his withdrawal a couple hours before he was scheduled to take the court at Indian Wells Tennis Garden.
Federer is on a five-matching winning streak against Nadal, who lost to him all four times they played in 2017.
Roger Federer defeated Kyle Edmund 6-1, 6-4 while Rafael Nadal got the better of Filip Krajinovic 6-3, 6-4.
Williams raced to a 3-0 lead over two-time major champion Garbine Muguruza in their third-round match before dropping six straight games and the first set, 6-3.
Roger Federer defeated Stefanos Tsitsipas 6-4, 6-4 in the final of the Dubai Championships on Saturday.
Federer's final hurdle in the tournament is Stefanos Tsitsipas of Greece who had shown him the door during the 2019 Australian Open.
Federer is looking to become the second man in the professional era to reach 100 tour-level tournament tiles, joining Jimmy Connors, who won 109.
Roger Federer skipped the entire clay season, including the French Open, in recent years to prepare well for the Wimbledon.
Virat Kohli met Roger Federer at the Australian Open after India's 2-1 ODI series win against Australia.
Stefanos Tsitsipas, 20, idolises Roger Federer, who at 37, was the oldest man left in the field and was bidding to become the oldest man to reach the quarterfinals in Australia since 1977.
14th seed Stefanos Tsitsipas defeated 3rd seed Roger Federer 6-7 7-6 7-5 7-5 in fourth round to knock the Swiss out of Australian Open.
A video showing Federer stopped by a security guard in a hallway outside a locker room at the Grand Slam tournament made the rounds on Twitter.
Kohli was at Melbourne Park on Saturday, a day after leading India to another series victory against Australia.
Roger Federer marked his 100th match on Rod Laver Arena by defeating American Taylor Fritz 6-2, 7-5, 6-2 in the third round.
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