Ravichandran Ashwin becomes the third Indian bowler to achieve the remarkable feat, alongside Anil Kumble and Harbhajan Singh.
Mohammed Shami, Umesh Yadav and Ishant Sharma are expected to be more than a handful during the series but Mithun seemed more wary about the Ashwin-Jadeja threat.
Yuzvendra Chahal is the third Indian to achieve the feat and 32nd overall.
Indian off-spinner Ravichandran Ashwin joined Delhi Capitals from Kings XI Punjab.
Delhi Capitals' head coach Ricky Ponting has reacted to the arrival of Ravichandran Ashwin to the squad.
Kings XI Punjab have traded Ravichandran Ashwin to Delhi Capitals for 1.5 crore and spinner Jagadeesha Suchith.
Stylish opener KL Rahul is expected to lead the side after Ravichandran Ashwin's departure.
Ashwin was supposed to join Delhi Capitals earlier but once Anil Kumble came on board, it was learnt that KXIP weren't ready to release their senior bowler.
Ravichandran Ashwin surprised everyone when he came in to bat at number 3, but he could now be fined for sporting the BCCI logo on his helmet.
In the recent series against South Africa which India won 3-0, Ashwin and Jadeja showed their prowess by emerging out as the leading wicket-takers from both the sides.
Ashwin, who bagged 15 wickets in the three Tests, will now head to Bengaluru to take part in the ongoing Vijay Hazare Trophy.
It has been learnt that the newly-appointed head coach Anil Kumble was also keen to retain Ashwin, who captained the side in the previous two editions.
Ashwin, who had entered the top 10 after the first Test in Visakhapatnam, has now moved to the seventh spot, courtesy his six wickets which he took against the Proteas in the second Test.
Ashwin, who had the best figures of 4 for 69 in 28.4 overs, lauded the 109-run ninth-wicket stand between Maharaj and Philander, stating that the word "tail-ender is a myth".
South Africa began the day at 36 for three but a rearguard action through Keshav Maharaj (72) and Vernon Philander (44) helped them cross the 250-run mark.
Ashwin joined an elite list of Indian bowlers who have taken 50 or more Test wickets against South Africa, which includes Anil Kumble, Harbhajan Singh and Javagal Srinath.
South Africa began the day at 36 for three but a rearguard action through Keshav Maharaj (72) and Vernon Philander (44) helped them cross the 250-run mark.
Ashwin's 350 in just 66 Tests places him fourth in the all-time list for India behind Kumble's 619, Kapil Dev's 434 and Harbhajan's 417.
While both had reached the milestone in their 66th Test, Ashwin took 18 innings more than Muralitharan, but bowled fewer deliveries than the former Sri Lankan cricketer
Ravichandran Ashwin took eight wickets in the first Test against South Africa and equalled the world record for the fastest bowler to take 350 wickets in Tests.
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