In his first trip to Roland Garros since 2015, Federer would be wrapping up a 7-6 (4), 4-6, 7-6 (5), 6-4 victory over Wawrinka, his friend and Swiss Olympic and Davis Cup teammate, to make his way to the semifinals.
Roger Federer is yet to drop a set in the French Open this year, while Nadal also cruised into the round-of-eight with an easy victory.
Roger Federer defeated Casper Ruud 6-3, 6-1, 7-6 while Rafael Nadal got the better of Belgian 27th-seeded David Goffin 6-1, 6-3, 4-6, 6-3
Federer returned to the French Open's third round with a predictably straightforward 6-4, 6-3, 6-4 victory over 144th-ranked Oscar Otte.
Rafael Nadal entered the second round at Roland Garros, but former World No.1 Caroline Wozniacki was stunned by 68th-ranked Veronika Kudermetova.
The defending champion was handed what looked like quite an easy draw on Thursday at Roland Garros stadium, where the Spanish player attended the ceremony and said he was happy with his form.
Roger Federer returns to the French Open for the first time since 2015. He missed the 2016 tournament because of back issues, ending his record streak of 65 consecutive appearances at major tournaments.
Djokovic has 12,355 points ranking first, followed by Spain's Rafael Nadal (7,945) and Roger Federer of Switzerland (5,950).
It marked the first time in an Open Era-record 54 meetings, and in their 142nd set against each other, that Nadal won a set against Djokovic without conceding a game — otherwise known as a bagel.
It will be the 54th career meeting between Djokovic and Nadal, with Djokovic leading the series 28-25. The pair has split the four Italian Open finals they've played.
Rafael Nadal took his revenge on Tsitsipas he beat the Greek 6-3 6-4 to enter the final of the Italian Open.
Rafael Nadal defeated Nikoloz Basilashvili 6-1, 6-0 while Novak Djokovic got the better of Philipp Kohlschreiber 6-3, 6-0 to move into the quarterfinals of Italian Open.
Asked who would end up winning most number of titles in men's singles, Sanchez said it is difficult for her to pick one because Roger Federer, Rafael Nadal and Novak Djokovic are great players and equally competent.
Federer saved all seven break points he faced to beat Joao Sousa 6-4, 6-3, then was to play Borna Coric for a spot in the quarterfinals.
Nadal's slump on clay continued on Saturday at the Madrid Open with a third consecutive semifinal elimination, adding to his worst start to the clay-court swing since 2015.
Nadal cruised to a 6-3, 6-3 win over Canadian teenager Felix Auger-Aliassime to reach the third round in the Spanish capital.
A somber Nadal announced his withdrawal a couple hours before he was scheduled to take the court at Indian Wells Tennis Garden.
Federer is on a five-matching winning streak against Nadal, who lost to him all four times they played in 2017.
Roger Federer defeated Kyle Edmund 6-1, 6-4 while Rafael Nadal got the better of Filip Krajinovic 6-3, 6-4.
Williams raced to a 3-0 lead over two-time major champion Garbine Muguruza in their third-round match before dropping six straight games and the first set, 6-3.
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