World No 5 Sindhu, a silver medallist at Rio Olympics and 2017 and 2018 World championship, defeated Indonesia's Choirunnisa 21-14, 21-9 in a lop-sided contest in women's singles.
Eighth-seeded India's hopes will now rest on their next match when they take on the mighty China Wednesday.
India first will look to quell the challenge of Malaysia on Monday before taking on the mighty 10-time champions China the next day.
Much was expected from fourth seed Sindhu but the Rio Olympic silver medallist was stunned by an unseeded local girl Cai Yanyan.
PV Sindhu defeated Indonesia's Choirunnisa 21-15 21-19 while Sameer Verma got the better of Hong Kong's Ng Ka Long Angus 21-12 21-19.
Sindhu looked in command from the beginning and registered a thumping 21-14, 21-7 victory in just 28 minutes against Japan's Takahashi Sayaka.
PV Sindhu defeated world No.18 Cai Yanyan of China 21-13, 17-21, 21-14 to set up a meeting with former world champion Nozomi Okuhara.
World number 6 Sindhu will next face China's Cai Yanyan, a 2017 BWF World Junior Championships bronze medallist.
Star Indian shuttlers P V Sindhu and Saina Nehwal sailed into the second round of the Singapore Open with straight-game wins over their respective rivals in the women's singles event here Wednesday.
Eighth-seeded Srikanth, who had reached the finals of a BWF World Tour event after 17 months at the India Open last week, defeated Thailand's Khosit Phetpradab 21-11, 21-15.
PV Sindhu defeated World No. 20 Aya Ohori 22-20 21-12 while Kidambi Srikanth got the better of Ihsan Maulana Mustofa 21-18 21-16.
Sindhu, a 2017 champion and 2016 finalist, edged out Denmark's eighth seed Mia Blichfeldt 21-19, 22-20 in a closely-fought contest to set up a clash with China's He Bingjiao.
PV Sindhu brushed aside fellow Indian Mugdha Agrey 21-8, 21-13 in women's singles.
PV Sindhu and Kidambi Srikanth will be expected to keep India's hopes afloat in the USD 350,000 India Open starting Tuesday.
Last week, Saina, who had reached the quarter-finals of the All England Championship, had broken the news that she was advised to get admitted to get treated for her illness.
World No.9 Nehwal went past the Scottish shuttler 21-17, 21-18 in the first round of women's singles.
Fifth-seeded Sindhu, who was beaten by Sung Ji twice in last three meetings, lost 16-21, 22-20, 18-21, despite saving as many as eight match points in the second and third game.
It was Sindhu and Saina's mentor and current chief national coach P Gopichand, who was the last Indian to win the championship back in 2001.
Terming the opportunity to fly Tejas as a great experience, the 23-year-old said that she is really "honoured."
Morten Frost believes that although there won't be any clear favourites but he is read to stick his neck out for the young Japanese woman.
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