The title-winning goal came in the 81st minute when De Bruyne whipped in a low cross to Gundogan, who tapped in from close range, sending the crowd into rapturous delight.
Cristiano Ronaldo's fifth goal in three games salvaged a point for Manchester United in a 1-1 draw against Chelsea that further damaged his team's chances of a top-four finish in the Premier League.
Ronaldo, who missed the 4-0 loss to Liverpool on Tuesday while grieving the death of his newborn son, raised his left arm and pointed to the sky after scoring in the 34th minute.
Burnley improved its chances of staying in the Premier League with a 2-0 victory over Southampton in the team's first home game since the surprise firing of Sean Dyche as manager.
Manchester City scored three times in the second half to reclaim top spot in the Premier League with a 3-0 victory over Brighton.
With the treble against Spurs, Ronaldo has lifted himself on top of FIFA's all-time scorers' list.
The league and its clubs have also decided to donate one million pounds (Rs 10.07 crore approx) to support the people of Ukraine.
Spurs took the lead after 14 minutes when Ryan Sessegnon's low cross was turned into his own net by Michael Keane.
Braces from De Bruyne and Mahrez sink Manchester United, who had a consolatory goal from Sancho.
Big screens at stadiums will display "Football Stands Together" against the backdrop of the blue and yellow colours of the Ukrainian flag. These words will also be shown on LED perimeter boards during matches.
Alisher Usmanov's companies USM, Megafon and Yota -- who had commercial sponsorship arrangements with the club -- were suspended with immediate effect, Everton said in a statement.
Chelsea owner Roman Abramovich had earlier announced that he will be handing the day-to-day functioning of the club to trustees.
In a stadium in northwest England, two Ukrainian footballers on opposite teams embrace prior to kickoff, before being brought to tears as teammates line up for a match wearing tops displaying the Ukraine flag and the message: “No War.”
The Italian manager questioned his future as Tottenham manager after seeing his team lose 1-0 at relegation-threatened Burnley on Wednesday.
Second-half goals from Fred and Elanga help the Red Devils beat their old rivals in a thrilling encounter at the Elland Road.
Stoppage time goal by the Tottenham striker helps his club beat table-toppers Manchester City 3-2 at the Etihad.
Bruno Fernandes added a second goal in the seventh minute of stoppage time, with virtually the last kick of the game
The Denmark playmaker featured in a practice match for Brentford, the London-based Premier League club he signed for last month to resume his playing career.
Kevin De Bruyne also netted for the fourth home game in succession in the league as City extended its unbeaten run to 14 matches in a title defense that is on course to finish in a sixth championship in 11 seasons.
Second-place Liverpool will have two games in hand going into their match against Leicester.
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