Mohamed Salah had put the champions in front from the penalty spot in the 13th minute after Kyle Walker’s foul on Sadio Mane.
With a third straight win, Leicester went top but could be overtaken if Liverpool win at Manchester City later Sunday.
Timo Werner wrapped up the scoring in the 80th after latching onto a ricochet that flew back toward United’s box.
The 25th-minute equalizer arrived when left back Luke Shaw had time and space to send over a cross that was met with a header from Fernandes from 12 yards (meters).
Southampton overcame the absence of injured top scorer Danny Ings to beat Newcastle 2-0, with fellow striker Che Adams and midfielder Stuart Armstrong scoring at St. Mary's.
The 28-year-old Ings came off late in the Saints' 4-3 victory over Aston Villa on Sunday. He had earlier scored his fifth goal of the season.
A lead protected this time, Jose Mourinho’s side climbed to second in the Premier League on the day his former club Manchester United lost 1-0 at home to Arsenal.
Arsenal hadn't beaten United away since an FA Cup game in 2015, part of a longstanding run of poor form for the Gunners when facing England's biggest clubs on the road.
Everton went into the game second only to Liverpool in the standings but has now lost three league games in a row.
Hakim Ziyech and Timo Werner scored in a 3-0 win over Burnley in the Premier League on Saturday, which came three days after a 4-0 victory in the Champions League at Krasnodar.
Walker collected a pass from Kevin De Bruyne in a central position, surged forward, and fired in an effort from 30 yards (meters) that found the bottom corner in the 28th minute.
Son headed in from Kane's flick-on to secure a 1-0 win at Burnley on Monday, making it the 29th time they have combined for a goal. It was the ninth time in six league matches this season alone.
Brighton took the lead five minutes before halftime when an attempted clearance from Branislav Ivanovic rebounded off Jake Livermore and into the back of the net.
Vardy had enough time to net his 11th league goal against Arsenal — the most he has scored against a single opponent in the competition.
Everton's worst display of the season was capped by the 71st-minute sending-off of left back Digne, who raked his studs down the back of Kyle Walker-Peters' leg as he chased after the Southampton right back.
Manchester United were held to a goalless draw by Chelsea at Old Trafford, as the Reds remain winless at home for three matches in a row since the season began.
It was 2014 and Mendy — aged 22 at the time — had been without a soccer club for a few months. Realizing unemployment benefit wasn’t going to be enough to provide for his family, he began to look for jobs outside the game he loved.
Just one across two games — and that being a fortunate deflected effort to earn Wolves a win at Leeds — ended the goal rush that had made the most-watched league in the world even more compelling viewing over the first five rounds.
Aston Villa are second in the Premier League with four wins in as many matches.
Cruising 3-0 when Bale came off in the bench in the 72nd minute against West Ham, Tottenham incredibly collapsed in a game it had been in control of to draw 3-3 in the Premier League on Sunday.
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