The Serb World No. 1 beat No. 6 seed Matteo Berrettini 5-7, 6-2, 6-2, 6-3 in a quarterfinal that began Wednesday night and concluded after midnight Thursday.
The Russian, who captured his 200th career win in the first-round victory against Richard Gasquet of France, defeated qualifier Botic van de Zandschulp in four sets.
No. 1 Djokovic improved to 25-0 in majors this year by winning 1-6, 6-3, 6-2, 6-2 against 20-year-old Jenson Brooksby.
Brooksby is a wild-card entry who began this season ranked outside the top 300 and is now a career-best 99th.
Djokovic moved into the fourth round at Flushing Meadows for the 14th consecutive appearance, coming back to beat Kei Nishikori 6-7 (4), 6-3, 6-3, 6-2.
Djokovic registered a 6-2 6-3 6-2 win over Dutchman Tallon Griekspoor to advance to the third round in US Open.
Djokovic's second-round match is against Tallon Griekspoor, who was moved into the main draw when Federer had to withdraw because of a knee injury.
Djokovic beat Danish qualifier Holger Vitus Nodskov Rune 6-1, 6-7 (5), 6-2, 6-1 to reach the second round.
No man has won the Australian Open, French Open, Wimbledon and U.S. Open in the same season since the slightly built, red-haired, left-handed Australian did it for the second time — yes, second — 52 years ago
Two years back, Medvedev had credited his US Open final appearance to the crowd, which had jeered the 25-year-old all through the tournament in 2019 till he reached the title showdown against Rafael Nadal.
The year's last Grand Slam tournament begins Monday — with full crowds allowed a year after all fans were banned because of the coronavirus outbreak
Novak Djokovic's quest to complete the calendar Grand Slam will begin against a qualifier following the release of the US Open draw.
Zverev defeated Russia's Andrey Rublev 6-2, 6-3 here on Sunday to lift his fifth ATP Masters 1000 title and become the first German champion in Cincinnati since Boris Becker in 1985.
Djokovic wrote on social media that he needs “a bit longer to recover and recuperate after quite a taxing journey from Australia to Tokyo.”
Djokovic will leave Tokyo without a medal as he lost the match for bronze against Spain's Pablo Carreno Busta.
Djokovic, the top-ranked Serb who had seemed invincible in all of the biggest tournaments this year, lost to Zverev 1-6, 6-3, 6-1 Friday in the semifinals of the tennis tournament at the Tokyo Olympics.
Djokovic was attempting to become the first man to win all four Grand Slam tournaments and Olympic gold in the same year.
The top-ranked Serb never gave Nishikori a chance in a 6-2, 6-0 rout of the home favorite from Japan to reach the semifinals of the tennis tournament at the Tokyo Olympics on Thursday.
Djokovic is attempting to become the first man to win all four Grand Slam titles and Olympic gold in the same calendar year.
Daniil Medvedev, representing the Russian Olympic Committee (ROC) team since Russia is banned, also won his first-round match against Alexander Bublik of Kazakhstan 6-4, 7-6(8).
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