Fati scored Spain’s third goal from outside the area in the 32nd minute to become the country's youngest scorer at the age of 17 years, 311 days.
Jose Luis Gaya scored a late equaliser after Timo Werner put Germany in the lead against Spain in the Nations League group game.
Kicking off with a meeting between recent World Cup winners Germany and Spain on Thursday, and ending next Tuesday with a rematch of the 2018 final between France and Croatia, there is plenty of high-quality matchups on the program.
Several Chelsea players reportedly tested positive for the virus upon returning from vacation, resulting in Jorginho being placed in isolation.
The group phase will start in September, after Portugal tries to retain their more significant title at the June 12-July 12 European Championship.
The only goal of the match came from midfielder Goncalo Guedes early in the second half at the Estádio do Dragao as Portugal beat Netherlands to win the Nations League.
The Netherlands took advantage of two sloppy defensive mistakes by England in extra time to earn a 3-1 win in the semifinals of the Nations League on Thursday.
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