A penalty from Batholomew Ogbeche (30th minute) and a header from Rowllin Borges (45th) gave Sergio Lobera's men their third win in four games and their first-win ever over Odisha in the league.
Mumbai's much touted attacking strength was on show against East Bengal with the likes of Ahmed Jahouh, Rowllin Borges and Adam le Fondre all making a mark.
Hugo Boumous assisted all three goals as a brace from Adam Le Fondre (20', 48') and a strike from Hernan Santana (58') saw Mumbai register their second straight win with SCEB yet to open their account.
Live Streaming ISL 2020-21 Mumbai City FC vs SC East Bengal: Find full details on when and where to watch MCFC vs SCEB Live Online on Disney+ Hotstar and TV Telecast on Star Sports.
Live Streaming ISL 2020-21 FC Goa vs Mumbai City FC: Find full details on when and where to watch FCG vs MCFC Live Online on Disney+ Hotstar and TV Telecast on Star Sports.
For Mumbai City head coach Sergio Lobera, it will be the first time he will be up against his former club which he guided to League Winners Shield last season and to the group stage of AFC Champions League.
Mumbai went in with two strikers up front with Adam Le Fondre playing as a makeshift right winger along with Bartholomew Ogbeche.
A red card and a penalty turned a game, that Mumbai were otherwise dominating, on its head and handed NorthEast United FC a winning start at the Tilak Maidan.
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Mumbai City have never won the coveted trophy and would be hoping that there is a turnaround in fortune under new coach Sergio Lobera, who had guided FC Goa to Super Cup win in 2019.
While 22-year-old Ranawade joins the Islanders on a one-year contract, 21-year-old Rohlupuia has inked a four-year deal.
A product of English club Tottenham Hotspur's youth academy, Goddard represented Spurs at the U-18, U-21 and U-23 levels before leaving in 2017.
The 25-year-old left-back, who was previously part of ISL side Chennaiyin FC, signed a two-year contract with the Islanders
The 22-year-old centre-back joins the Islanders on a three-year contract which will keep him at the club until 2023.
Mumbai City head coach Sergio Lobera described the Nigerian as a top-class player.
The 33-year-old Englishman joins the ISL side ahead of the 2020-21 season, bringing in tons of experience and quality to the Mumbai City FC attack.
Mumbai City FC assistant coaches Marco Leite and Pedro Miguel Correia will also be leaving the club.
Clear-cut chances were few and far between in what was an intense contest that saw Mumbai City reduced to 10-men in the second half.
A recent change in coaching staff, with Clifford Miranda taking over as interim coach from Sergio Lobera, has made a positive impact on their on-field performance. FC Goa scored a convincing 4-1 win over Hyderabad FC in their last game.
A first-half goal from Diego Carlos (44') was all that Jorge Costa's men needed to notch an important win at home while NorthEast United went a fourth successive game without scoring.
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