Liverpool travel to Napoli, where they lost in the group stage last season, while Barcelona visit Borussia Dortmund as the Spanish giant renews their search for a first European title since 2015.
Newcastle left-back Jetro Willems took full advantage of Liverpool's slow start to score the opener, but Mane's goals and a strong contribution from substitute Roberto Firmino saw Liverpool take the win.
Liverpool defeated Burnley 3-0 while Sheffield United came back from being 2-0 down to earn a point against Chelsea at Stamford Bridge.
Liverpool, Manchester City, Chelsea are all in the pot of eight top-seeded teams along with Barcelona, Juventus, Bayern Munich, Paris Saint-Germain and Zenit St. Petersburg.
Liverpool are now the only side to score a maximum nine out of nine points in the first three games of the Premier League this season as they beat Arsenal 3-1 at Anfield.
Adrian turned penalty hero with a save on the final kick of the shootout as Liverpool beat Chelsea to win the Super Cup and kick off a new European season.
Frank Lampard said that he believes in the players and feels that despite the 4-0 defeat to Manchester United over the weekend, Chelsea can still beat Liverpool in the UEFA Super Cup.
Alisson went off in the first half of Liverpool's 4-1 win over Norwich on Friday, leaving new signing Adrian as the club's only fit senior goalkeeper.
Jurgen Klopp also admitted that despite signing Adrian, Liverpool are short of keepers as their third senior keeper Caoimhin Kelleher works to recover from a broken bone in his hand.
Jurgen Klopp's side registered an emphatic victory over Norwich City to kickstart their Premier League campaign.
Jurgen Klopp's Liverpool gave an early statement of intent as they scored four past the newly-promoted Norwich City, but faced a massive injury setback.
Manchester City netted all five penalties — the last by Gabriel Jesus — and goalkeeper Claudio Bravo made a key save to deny Georginio Wijnaldum's attempt in a 5-4 shootout win.
Despite finishing with 10 men and facing an increasingly hostile crowd, Alejandro Pozo scored in the 90th minute on an assist from Munir El Haddadi to give the Spanish side a 2-1 victory.
Fernando Torres made 110 appearances for Spain, netting 38 goals and won the 2010 World Cup and the 2008 and 2012 Euro.
The Premier League schedule for the 2019-20 season was announced Thursday with the highlight of the opening round being Manchester United at home against Chelsea.
After losing his last six cup finals, Juergen Klopp finally won a trophy on Saturday but Tottenham's Mauricio Pochettino failed to win his first title as a coach despite being agonisingly close to one.
Mohamed Salah and Divock Origi scored for Liverpool as they beat Tottenham 2-0 at the Wanda Metropolitano to lift their first European title in 14 years.
Liverpool will be looking to win their sixth Champions League title while Tottenham Hotspur will win the champions for the first time if they can overcome their rivals at the Wanda Metropolitano in Madrid.
The return of Harry Kane and Mohamed means Lucas Moura and Divock Origi could miss out on a starting berth for Tottenham and Liverpool respectively in the Champions League final.
With just eight days until kick off, those looking to book hotel accommodation for the weekend of June 1 will find that the price per night has doubled or even tripled, as is usual with this type of event.
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