The penalties came toward the end of each half as Ronaldo — who appeared bothered by a bloody cut to his ankle during the pre-match warmup — matched David Trezeguet’s streak from 2005.
Instead, Milan recalled Diego Laxalt from Torino, where the Uruguay fullback had been on loan.
Juventus, who have won the competition a record 13 times — including four of the past five editions — will face AC Milan or Torino in the two-legged semifinal.
Ronaldo did not score at all in November, but he scored twice as Juventus beat Parma 2-1 on Sunday to take his tally to 11 in his last seven league matches.
Half a season into his tenure at Juventus, it’s often been difficult to discern traces of “Sarri-ball,” the style of mesmerizing short, vertical passes that boosted Sarri to prominence first at Empoli then at Napoli.
Goals from Merih Demiral and Cristiano Ronaldo in the opening 10 minutes moved the Bianconeri two points ahead of Inter Milan, who were held 1-1 by Atalanta a day earlier, at the halfway stage of the season.
On loan at Parma from Atalanta, the 19-year-old has managed four goals and seven assists in 17 league games so far this season, catching the eye of clubs like Inter Milan and Liverpool.
Inter Milan lead the Serie A charts with 42 points along with Juventus but the former are ahead because of a better goal difference while Lazio are third with 36 points.
The move ends speculation that Mario Mandzukic was a possible target for Manchester United.
Juventus beat Sampdoria 2-1 courtesy of another Cristiano Ronaldo special to return to the top of Serie A standings.
It was the fourth successive match Ronaldo has scored in, with the Portugal international having a fantastic month after not scoring in the whole of November.
Juventus were already assured of topping Group D and seemed sluggish at times in Germany, before Ronaldo scored from close range off substitute Paulo Dybala's cross in the 75th minute.
Ronaldo put the visitors in the lead after 25 minutes from close range after Rodrigo Bentancur's assist but Juve's defense was caught off guard on a corner kick just before the interval as Felipe equalized.
Juventus needed a Cristiano Ronaldo penalty to secure a point against Sassuolo and Inter Milan beat Spal 2-1 a few hours later to move a point above the Bianconeri in the Serie A table.
League leaders Juventus maintained its one-point advantage over Inter Milan, who won at Torino 3-0.
The club also expects an apology from Ronaldo who escaped both a fine and a ban for his reaction when head coach Maurizio Sarri took him off after 55 minutes.
Ronaldo was replaced by Paulo Dybala with the Italian champions in search of a goal. Dybala, however, proved Sarri right as he scored the goal in the 77th minute.
Sarri hauled off Ronaldo after just 55 minutes of their Serie A showdown. The Portugal international was replaced by Paulo Dybala with the Italian champions in search of a goal.
Milan had the better of the chances but substitute Dybala netted 13 minutes from time to secure victory for the eight-time defending champion.
Lokomotiv Moscow levelled after Juventus took an early lead and looked headed for a point before a moment of individual brilliance from Douglas Costa helped Juve clinch the tie.
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