Star forward Cahill is available for selection in Jamshedpur FC, while Dhanachandra Singh will remain unavailable due to his injury woes.
Chennaiyin FC coach John Gregory said the team will look to bounce back after the loss to Bengaluru FC in the opener.
The home side, who kicked off the fifth ISL season with a 0-2 loss to Kerala Blasters, were reduced to 10 players in the 32nd minute
The hosts will try to notch up a win in front of their home supporters at the Jawaharlal Nehru Stadium.
Mumbai have roped in foreigners Paulo Machado (Portugal) and striker Rafael Bastos (Brazil), coupled with new Indian faces like Souvik Chakrabarti, Raynier Fernandes and Subhashish Bose.
For four successive years, NorthEast United FC have tried but failed to win a place in the playoffs.
Bengaluru were the best side in the previous edition, winning 13 of their 18 matches to qualify for the playoffs with four games to spare.
Kerala Blasters FC (KBFC) rode on second-half strikes from Matej Poplatnik and Slavisa Stojanovic to beat Atletico de Kolkata (ATK) 2-0.
India's all-time highest scorer, who is also among the top five in international football, said they are looking forward to the 2019 AFC Asian Cup.
The 34-year-old had an impressive last season with FC Goa, clocking well over 1500 minutes on the field with 13 goals and six assists to his name.
Grassroots coach, Naresh Virnodkar has been handed the role as coach of the team as training for the league has begun at the Chowgule Sports Centre in Margao.
Chennaiyin FC has already retained 13 players from last season for their title defence, with head coach John Gregory and sports scientist Niall Clark also signing one-year extensions.
Popovic joined the club in September 2017 and made a lasting impression helping FC Pune City breach the top-four barrier, a first time in the club's four-year history.
Under the former Real Madrid player, Dynamos finished eighth in the league standings and were beaten in the qualifying rounds of the inaugural Super Cup.
The first English coach to win the ISL trophy, Gregory led Chennai to an eight-match unbeaten run that culminated in a 3-2 victory over Bengaluru FC in the final, thus securing qualification to the 2019 AFC Cup.
This was Chennaiyin FC's second title triumph in the ISL, tying them with ATK as the most successful team in the tournament.
Chennaiyin now face Bengaluru FC at the grande finale on March 17 at Sree Kanteerava Stadium in Bangalore.
Chhetri could have had another goal with a curler in 72nd minute, which was saved by a diving Kaith.
Backed by a vociferous home crowd, FC Goa went into attacking mode from the start and enjoyed better share of ball possession.
In the nine matches the two sides have played, Goa won four and Chennaiyin five, including the famous final in 2015.
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