Following the draw, Italy will need to get through two one-leg matchups to advance in a newly devised playoff system.
Lionel Messi will play for Argentina when they face Brazil on Tuesday in World Cup qualifier while Neymar will miss out because of left thigh pains.
Argentina coach Lionel Scaloni said Monday that Messi, who has been bothered by a knee injury, will play in San Juan in a match that could earn the team a spot in next year's World Cup.
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Veteran winger Angel di Maria scored the only goal in the seventh minute with a powerful left-foot shot while Messi missed most of the match as he recovers from a left knee injury.
Argentina can secure a World Cup spot if it beats Brazil and if two of three other teams — Uruguay, Chile and Colombia — fail to win but will have to do so without injured Lionel Messi.
Mitrovic's 90th-minute header left Cristiano Ronaldo and Portugal stunned in a 2-1 win for Serbia in Lisbon, which gave Serbia an automatic qualifying spot at the World Cup in Qatar.
Italy lose further three players as Alessandro Bastoni and Davide Calabria are both injured while fellow defender Cristiano Biraghi has returned home because of personal reasons.
Christian Benteke, who replaced Lukaku up front, put the hosts in front early and Yannick Carrasco made it 2-0.
Cristiano Ronaldo’s chance to play at possibly his last World Cup could hinge on the result of Portugal's winner-take-all clash against Serbia.
Italy's injury problems continued to pile up as captain Giorgio Chiellini became the latest player to withdraw from the squad on Wednesday ahead of its final World Cup qualifiers.
Brazil has 31 points and Argentina has 25 from 11 matches — their encounter in September was bizarrely suspended after seven minutes of play because of concerns from authorities over breaches of COVID-19 protocols.
A 1-0 win over Latvia with a volley from Davy Klaassen lacked the swagger from last month's 6-1 dismantling of Turkey.
Leaders Brazil and second-place Argentina had uninspiring performances in their World Cup qualifying matches on Thursday, but gained key competition points.
FIFA is hoping the British government eases the quarantine requirements for players in time for the next set of World Cup qualifiers in October.
Just minutes into their match on Sunday, a Brazilian health official entered the pitch to remove four Argentina players.
Brazil topped Chile 1-0 in Santiago in a tense match despite the absence of nine of its England-based players, while Argentina beat Venezuela 3-1 at the Olimpico Stadium in Caracas.
Less than two months after winning the European Championship at Wembley, Italy was held to a 1-1 draw by Bulgaria in World Cup qualifying on Thursday.
Ronaldo scored twice in the final minutes of the match to set up a 2-1 win for Portugal.
Bergwijn, who has scored one goal in 12 appearances for his country, has been a prominent part of Tottenham's successful start this month.
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