Manchester City threatened an amazing comeback after goals by substitute Bernardo Silva, in the 84th, and Ilkay Gundogan, in the first minute of stoppage time, but Liverpool held on in a nervy finale.
Arsenal isn't even in City's slipstream but floating far from the leaders, sitting adrift by 23 points and actually closer to the relegation zone by four points.
All four goals came in the final half hour of a game that left third-place and defending champion Chelsea 16 points behind Manchester City and Arsenal 23 adrift of the leaders.
Raheem Sterling gave City lead inside a minute - he has now scored the earliest and latest goals in the league this season - before Christian Kabasele's own goal and a close-range finish from Sergio Aguero put City 3-1 up.
Ragnar Klavan headed home the winning goal at Turf Moor as Liverpool earned a hard-fought victory without three of its "Fab 4" attack, with Roberto Firmino demoted to the bench and both Philippe Coutinho and Mohamed Salah declared injured.
Failing to clinch their 19th straight victory, City could not equal the landmark set by Pep Guardiola's Bayern Munich in the 2013-14 season of the record winning streak in Europe's top five leagues.
Chelsea, another team fighting for a finish in the Champions League qualification positions, had it much easier in a 5-0 victory over a depleted Stoke side at Stamford Bridge.
By beating Swansea 4-0 on Wednesday, City racked up its 15th straight victory — a feat never achieved in the 129-year history of England's top division.
Pogba was sent off for a studs-first tackle on Hector Bellerin in United's 3-1 win over Arsenal on Saturday.
It was a pulsating contest from start to finish at Emirates Stadium, with a glut of shots on goal, amazing goalkeeping, a sending off, and textbook counter-attacks.
Manchester City has re-established its eight-point lead over second-place Manchester United thanks to their 12th straight league win.
Pep Guardiola's Manchester City defeated Huddersfield 2-1 on Sunday to equal a club record 11th straight Premier League win.
Salah scored the opening goal for Liverpool - his 15th in 20 appearances this season - against the club that sold him last year.
Zlatan Ibrahimovic returned from a seven-month injury layoff in Manchester United's 4-1 victory over Newcastle in the English Premier League on Saturday.
Playing four days after beating Real Madrid in the Champions League, Tottenham was without forward Dele Alli, centre-back Toby Alderweireld and goalkeeper Hugo Lloris because of injury.
Xherdan Shaqiri levelled once for Stoke, and substitute Peter Crouch equalized the second time with a header in the 73rd minute.
The victory lifted Liverpool to level on points with top-five sides Chelsea and Arsenal, who face tough challenges against Manchester United and City, respectively, on Sunday.
Stoke, England: Southampton's bid for a Champions League berth was undermined when it conceded a late goal in a 2-1 loss to Stoke in the English Premier League on Saturday.Charlie Adam, scorer of a wonder
London: Manchester United fans were the worst troublemakers in the English Premier League (EPL), says a report from the British Transport Police (BTP).The report said Manchester fans sparked more trouble on trains than any other
London: Swansea striker Bafetimbi Gomis collapsed during an English Premier League game at Tottenham on Wednesday and was taken to a hospital as a precautionary measure.The France striker was attended to by medical staff for
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