Stokes was not scheduled to take part in white-ball matches till seven COVID-19 cases in the regular team forced the entire squad into self-isolation.
Captain Azam hit 85 from 49 balls and Rizwan 63 from 41 in a Pakistan record total of 232-6.
England vs Pakistan Live Streaming 1st T20I: Find full details on when and where to watch ENG vs PAK 1st T20I Live Streaming on SonyLIV.
Pakistan also lost their middle order batsman, Haris Sohail, to a leg injury before the start of the three-match ODI series where they lost 3-0.
Afridi said that the present Pakistan team had the potential to match the exploits of the Younis Khan-led 2009 side which won the World T20 in England in 2009.
Pakistan was whitewashed in the three-match series with the biggest blow coming on Tuesday when it lost after scoring 331.
Eoin Morgan, England's white ball skipper, is among the nine first-choice players included in the squad for the T20I series against Pakistan starting July 16.
Pakistan conceded a 0-3 defeat to an England squad which was arranged merely two days prior to the start of the ODI series.
James Vince fine century helped his side defeat Pakistan by three wickets to make a clean sweep of the three-match One-day International series.
Pakistan cricket team misery continued in England when the side slumped to a 0-3 series loss in Birmingham despite Babar Azam's fluent 158-run knock.
Vince's first international hundred led England as they chased down 332 at Edgbaston and overcame a 158 by Pakistan captain Babar Azam.
The former pacer predicted a 0-3 ODI series loss for Pakistan after they lost the first two ODIs with dismal performances.
A four-wicket haul by Saqib Mahmood set the tone as a new-look England side comprising five debutants thrashed Pakistan by nine wickets.
Mahmood seized the unexpected opportunity 10 months since his last international appearance, taking two wickets in the first over of the day and finishing with career-best figures of 4-42.
An entirely new England squad was scrambled together on Tuesday, a day after the main squad recorded seven positive tests for the coronavirus.
England vs Pakistan Live Streaming 1st ODI: Find full details on when and where to watch ENG vs PAK 1st ODI Live Streaming on Sony LIV.
An MRI scan conducted on Wednesday revealed that the 32-year-old batsman has a grade three tear injury.
The ODI series between Pakistan and England commences at Cardiff on July 8.
England's revised, hastily assembled ODI squad includes nine new caps and will be captained for the first time by Ben Stokes.
As many as seven members of England cricket team -- including four staff members -- have tested positive for COVID, confirmed England and Wales Cricket Board.
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