Santana's twin burst came in the 56th minute after SC East Bengal scored their first ever ISL goal through Jacques Maghoma in the 26th minute.
Fowler had earlier criticised the standard of refereeing, especially after their match against NorthEast United FC where they were denied two penalties.
SC East Bengal will on Thursday take on a resurgent Jamshedpur FC who halted ATK Mohun Bagan's three-match winning run with a 2-1 victory.
SC East Bengal are currently the only side yet to open their account in the 11-team top-tier league.
An own goal by Surchandra Singh handed NorthEast United a 33rd minute lead in an intense first-half that saw the red-and-gold's penalty claims being rejected by the referee.
The red-and-gold brigade, who were the last to join the ISL, kicked off their campaign with a 0-2 derby defeat to Mohun Bagan, followed by a 0-3 debacle against Mumbai City FC.
Hugo Boumous assisted all three goals as a brace from Adam Le Fondre (20', 48') and a strike from Hernan Santana (58') saw Mumbai register their second straight win with SCEB yet to open their account.
Live Streaming ISL 2020-21 Mumbai City FC vs SC East Bengal: Find full details on when and where to watch MCFC vs SCEB Live Online on Disney+ Hotstar and TV Telecast on Star Sports.
Krishna, who had scored ATKMB's lone goal against Kerala Blasters in their campaign opener, struck in the 49th minute before Manvir Singh killed the contest in the 85th minute with a solo effort.
Live Streaming ISL 2020-21 East Bengal vs ATK Mohun Bagan: Find full details on when and where to watch SCEB vs ATKMB Live Online on Disney+ Hotstar and TV Telecast on Star Sports.
There is, perhaps, no better match for Robbie Fowler to begin his stint in India than the Indian Super League's first-ever Kolkata derby. The man is, after all, the king of derbies.
Three cricketers, including Abhishek Raman and Writtick Chatterjee of East Bengal and Mohun Bagan, on Friday tested positive for COVID-19.
Newest entrants in the Indian Super League, East Bengal, along with Odisha FC, NorthEast United FC, Kerala Blasters and Hyderabad FC were the five clubs who had failed to meet the AFC and national licensing criteria.
Odisha FC, NorthEast United FC, Kerala Blasters, Hyderabad FC and new entrants East Bengal are the five clubs which were not handed licenses by the AIFF.
With ISL beginning late November, East Bengal members have requested club's new investors to form a reserve team for 123rd edition of prestigious IFA Shield.
Lyngdoh will make a comeback from injury in the upcoming Indian Super League season with SC East Bengal.
Neville has had the experience of playing under new East Bengal coach Robbie Fowler at the Roars till last season.
Newly-appointed East Bengal head coach they would aim to create a team which dominates ball possession.
The former Liverpool striker is expected to join the team in a week time in Goa ahead of the ISL season kick-off.
Bhutia said the club would face difficulties in making up a squad and should look to build a team for the long-term.
Top News
Latest News
