Barcelona remained in ninth place in the league and with their horizon of success narrowing to simply securing a top-four finish to ensure their spot in the Champions League.
The game marked Madrid's return to the Santiago Bernabeu Stadium more than 18 months after it was closed because of the coronavirus pandemic and a massive renovation project.
Barcelona played a man down from the 83rd after defender Clément Lenglet was sent off as Santi Mina brace nullified Messi's 30th goal of the season.
Barcelona vs Celta Vigo Live Streaming: Find full details on when and where to watch ATH vs RM Live Online on Facebook.
Luis Suárez scored an early goal to help Atlético Madrid win 2-0 at Celta Vigo and end the team’s scoring drought in the Spanish league on Saturday.
Barcelona won comfortably despite playing more than half the game with 10 men after defender Clément Lenglet was sent off before the break.
Barcelona lost the league lead after drawing at Sevilla two rounds ago. Madrid has yet to lose points after the pandemic break.
Celta Vigo clinched an equalizer four minutes before the final whistle but Real Madrid stay at the top of the La Liga table.
It was the 34th La Liga treble for Lionel Messi, tying former Real Madrid star Cristiano Ronaldo for the most in the competition as Barcelona beat Celta Vigo 4-1.
Real Madrid plays Villarreal in the final round of the Liga before the Champions League final on May 26 in Kiev.
The leaders had the lead till Samuel Umtiti suffered an injury which gave Iago Aspas a chance to draw level with the hosts at the Camp Nou.
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Barcelona (Spain), Mar 11: Cristiano Ronaldo ensured there was no letdown for Real Madrid after its win over Manchester United by scoring twice in a 2-1 victory at Celta Vigo on Sunday, lifting the team
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