Mandhana, who peppered the off-side field repeatedly with some gorgeous shots to reach 80 off 144 balls with 15 boundaries and a six, added 93 for the opening stand with Shafali Verma (31 off 64 balls), who played the second fiddle during their partnership.
With the third ODI held on Sunday and the following day being a rest day, the Mithali Raj-led squad has got only two practice sessions in the lead up to the landmark Test.
Australia thus took a 2-0 lead in the three-match WODI series and India's fragile bowling attack will now come under the scanner.
Australia Women vs India Women Live: Find live updates from the 2nd ODI between Australia and India in Mackay.
India badly need Shafali Verma and Smriti Mandhana to fire to put pressure on Australia after receiving a nine-wicket hammering in the opening match of the three-game series.
Head coach Matthew Mott said Vlaeminck, who did not bowl on Thursday, would be the lone player unavailable for next week's ODIs in Mackay and the ensuing Test in Gold Coast.
With Sydney and Melbourne being COVID-19 hot-spots, the Indian team and 12 out of the 18 Australian players are currently in a two-week hard quarantine.
India and Australia are set to battle it out across all three formats from next month.
It was in May 2021 that Megan announced that her wife Jess was expecting their first child with due date set for early November.
The Australian women's team's seasoned campaigners Megan Schutt and Jess Jonassen have opted out of the upcoming multi-format home series against India due to various reasons.
The Australian captain cited the recent rain-affected drawn game between India and England to call for the change.
The first women's international between India and Australia was a one-off Test at the WACA in January 1977.
The 31-year-old Healy, a veteran of 78 ODIs and 118 T20 matches, smashed six boundaries during her 50-minute stay at the crease.
This was Australia's 23rd consecutive ODI win and they have taken a 2-0 lead, thus sealing victory in the three-match ODI series.
The Australian women’s team beat New Zealand by 232 runs Wednesday to record its 21st consecutive win in one-day international cricket and equal a world mark set by Ricky Ponting’s Australian men’s team in 2003.
In absence of Meg Lanning nor Ellyse Perry, Australia on Wednesday probably produced their their most comprehensive performance of the past fortnight at the Allan Border Field.
For Australia, leg-spinner Georgia Wareham (2/23) starred with the ball and she was well supported by Jess Jonassen and Sophie Molineux who both scalped two wickets apiece.
With the win, White Ferns also ended a 13-match white-ball losing streak against their trans-Tasman rivals.
Perry, who tore her right hamstring during the Women's T20 World Cup in Australia in March, had hoped to resume against the Kiwis but aggravated the injury during training.
Australia first bundled New Zealand for 128 in 19.2 overs, with the innings punctuated by another contentious White Ferns dismissal and then chased down the target with more than three overs to spare.
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