Serena Williams became the latest Grand Slam champion to pull out of the Miami Open in order to concentrate on her recovery from recent oral surgery.
Novak Djokovic, Rafael Nadal and Roger Federer announced earlier they would withdraw from the tournament.
"Miami is a special tournament for me because it's my home. I am sad I won't be able to see the incredible fans this year, but I look forward to coming back soon," said Serena, who lives in Florida, in a statement according to BBC Sport.
The former world No. 1 is an eight-time winner in Miami. Williams' most recent match was a month ago at the Australian Open, where she lost to Naomi Osaka from Japan in the semi-finals.
Former world No.1 Andy Murray, who has fallen to 118 on the ATP rankings due to a long injury layoff, has been given a wildcard for the tournament.