Nadia Podoroska is the first female qualifier in the Open Era to reach the French Open semifinals.
The 131st-ranked Argentine tossed her racket high into the air after beating third-seeded Elina Svitolina 6-2, 6-4.
Podoroska could meet another qualifier in the semifinals if Martina Trevisan beats Iga Swiatek later.
Earlier, Danielle Collins reached the quarterfinals for the first time at Roland Garros after beating 30th-seeded Ons Jabeur 6-4, 4-6, 6-4.
The unseeded Collins next faces No. 4 Sofia Kenin in an all-American contest.
Collins looked in control at 3-0 up in the second set but her Tunisian opponent won five straight games.
Jabeur reached the Australian Open quarterfinals this year. This was her best run at the French Open while Collins had never previously been past the second round here.
Collins could reach her second semifinal at a major tournament after last year's Australian Open.