All four players have reached the U.S. Open final while only Nishikori hasn't won it to make this the first Grand Slam final four since the 2012 Australian Open in which all four players were past finalists.
Djokovic moved a step closer to a third championship at Flushing Meadows and 14th Grand Slam title overall by eliminating John Millman, who conquered Roger Federer in quarterfinals of US Open 2018.
Both players won, Osaka decisively and Nishikori narrowly to give Japan a men's and women's semifinalist at the same Grand Slam tournament for the first time.
The 14th-seeded Keys reached her third semifinal in the past five majors by using her big-strike game built on serves and forehands to overpower no. 30 Carla Suarez Navarro.
Naomi Osaka raced to a 3-0 lead in the first set and then 4-0 in the second, never giving the shaky Tsurenko a chance to get into her first major quarter-final.
The defending champion and No. 1 seed at Flushing Meadows recovered from his disastrous start and other stumbles along the way to beat No. 9 Dominic Thiem.
Williams put aside some early shakiness and an early deficit, turning things around with an eight-game run en route to a 6-4, 6-3 victory over No. 8 seed Karolina Pliskova for a spot in the semifinals.
Stephens beat Sevastova in the same round last year en route to her first Grand Slam title, but she missed numerous chances resulting in a loss.
Maria Sharapova won the US Open as a teenager. More than a decade later, she can't seem to make it past the fourth round.
Roger Federer suffered a shocking 3-6, 7-5, 7-6 (7), 7-6 (3) defeat to 55th-ranked John Millman of Australia in the fourth round of the 2018 US Open.
Williams reached the quarter-finals at Flushing Meadows for a 10th consecutive appearance by picking her level up after a lull and using 18 aces to beat Kaia Kanepi of Estonia 6-0, 4-6, 6-3.
The No. 2-seeded Federer moved into the fourth round at Flushing Meadows for the 17th consecutive appearance. He's won five titles at the U.S Open, although the last arrived a decade ago.
The No.1-ranked Nadal overcame a shaky start and used his customary relentless style to wear down No. 27 seed Karen Khachanov physically and mentally.
Serena equalled her most-lopsided victory against her sister with a 6-1, 6-2 rout in the third round of the U.S. Open.
The US Open says it regrets that a player was given a code violation for changing her shirt on the court during a match, clarifying its rules on when that is allowed.
Djokovic wasted a match point in the third set, before going on to win 6-1, 6-3, 6-7 (2), 6-2 against Sandgren.
Federer was crisp in a 7-5, 6-4, 6-4 win over Benoit Paire in and made it 18 of 18 lifetime in the second round of the U.S. Open.
Andy Murray lost to no. 31 seed Fernando Verdasco 7-5, 2-6, 6-4, 6-4 in the second round of US Open 2018.
Schnyder is ranked 186th, so she had to go through qualifying rounds to make it into the main draw and she became the oldest woman to successfully do that at any Grand Slam tournament.
Serena Williams set up the highly anticipated matchup at Flushing Meadows by hitting 13 aces and overwhelming 101st-ranked Carina Witthoeft of Germany.
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