Prajnesh Gunneswaran advanced to the second round of the Australian Open qualifiers but Ramkumar Ramanathan frittered away a one-set advantage to make an exit, here Tuesday.
Prajnesh knocked out local wild card Harry Bourchier 6-2 6-4 to set up second-round clash with Germany's Yannick Hanfmann.
Ramkumar led against 15th seed Argentine before losing steam to suffer a 6-4 4-6 1-6 defeat to yet again collapse in the Qualifiers of a Grand Slam.
Prajnesh had last year competed in main draws of all four majors of the season.
Sumit Nagal, who enjoyed a breakthrough 2019 season, will open his campaign in the qualifiers against Egypt's Mohamed Safwat.
In the women's qualifiers, India's lone contender Ankita Raina went down fighting 2-6 6-7(2) against Bulgaria's Viktoriya Tomova.