Angelique Kerber is the only major winner remaining in the Australian Open women's draw after ending Maria Sharapova's comeback tour to Melbourne Park. The 2016 champion routed Sharapova 6-1, 6-3 in the third-round match on Saturday night to extend her winning streak to 12 matches, including winning the Sydney International title last week.
Five-time major winner Sharapova was back at the Australian Open for the first time since 2016, when a failed test for Meldonium led to a 15-month doping ban.
It was all over in one hour and four minutes, a vast contrast to top-ranked Simona Halep's 4-6, 6-4, 15-13 win in three hours, 45 minutes over American Lauren Davis in the opening match on Rod Laver.
Halep will play Naomi Osaka, who beat 18th-seeded Ashleigh Barty 6-4, 6-2 in a match that was moved from the centre court to Margaret Court Arena because of the two long matches on Rod Laver.
No. 20 Barbora Strycova beat U.S. qualifier Bernarda Pera 6-2, 6-2, leaving U.S. Open finalist Madison Keys as the only American woman to reach the fourth round.
Keys advanced 6-3, 6-4 over Ana Bogdan and will next play No. 8 Caroline Garcia, who beat Aliaksandra Sasnovich 6-3, 5-7, 6-2.
Sixth-seeded Karolina Pliskova beat No. 29 Lucie Safarova 7-6 (6), 7-5 in a match featuring just one service break.
On the men's side, Hyeon Chung took out a Zverev for the second time this week. Chung beat fourth-seeded Alexander Zverev 5-7, 7-6 (3), 2-6, 6-3, 6-0 six days after a win over No. 32 Mischa Zverev in the first round.
Another unexpected loss at a major had the highly-touted Zverev admitted he may have a problem.
"Definitely not physical, so... I have some figuring out to do, what happens to me in deciding moments in Grand Slam," he said.
The 20-year-old Zverev has five titles on the elite tour but his fourth-round exit at Wimbledon last year remains his best run at a major.
Tomas Berdych ended 2009 U.S. Open champion Juan Martin del Potro's return to Melbourne Park for the first time since 2014 with a 6-3, 6-3, 6-2 win.
Fifth-seeded Dominic Thiem beat Adrian Mannarino 6-4, 6-2, 7-5 to set up a fourth-round match against Tennys Sandgren, who continued his career-best run by beating Maximilian Marterer 5-7, 6-3, 7-5, 7-6 (5).
Former world junior No. 1 Marton Fucsovics beat Nicolas Kicker 6-3, 6-3, 6-2 and No. 25 Fabio Fognini overcame Julien Benneteau 3-6, 6-2, 6-1, 4-6, 6-3.