Bordeaux fell 2-1 to visiting Maccabi Tel Aviv to leave the French club in trouble with zero points. Lyon, meanwhile, did only a little better in drawing 1-1 against Guimaraes.
Dimitris Salpingidis has scored many clutch goals for Greece, and the stocky striker did it for his club PAOK on Thursday when an injury-time goal canceled out Jeffrey Gouweleeuw's score in the 82nd as the Dutch club looked on course for three points.
At Sevilla, Fallou Diagne's sending off in the 62nd led to Diego Perotti's penalty score, and Sevilla held on to beat Freiburg 2-0 with Colombian striker Carlos Bacca adding the second in stoppage time.
Sevilla's second victory in the competition is twice as many as it has managed in seven league games this season.
"This victory will allow us to gain some confidence and improve," Sevilla coach Unai Emery said.
Wigan's 3-1 victory over Slovenian champion Maribor also came on its first ever home game in Europe.
PSV Eindhoven bounced back from a home loss to Bulgarian minnow Ludogorets Razgrad with a 2-0 win at Chornomorets Odesa. Ludogorets Razgrad continued its encouraging start with a 3-0 victory against Dinamo Zagreb in Group B.
