For Belgium, though, it will be a first World Cup in 12 years after the country's so-called golden generation topped Group A with a 2-1 win in Croatia, with striker Romelu Lukaku scoring twice.
"It's a party in Belgium. What more can you ask?" said coach Marc Wilmots, whose team played in front of Belgian Prime Minister Elio Di Rupo in Zagreb.
Switzerland prompted a jubilant tweet from tennis great Roger Federer after beating Albania 2-1 to win Group E with a game to spare and advance to the World Cup for a third successive occasion.
"Switzerland made it to the World Cup, how happy am I on a scale 1-10?" Federer wrote. "About a 25."
Spain beat Belarus 2-1 through second-half goals by Xavi Hernandez and Alvaro Negredo and requires just one point from a home match against Georgia to guarantee the world champions will defend their title next summer.
England stayed top of Group H, a point clear of Ukraine, after an impressive second-half display sealed a 4-1 win over Montenegro, with in-form strikers Wayne Rooney and Daniel Sturridge and debutant Andros Townsend among the scorers. The English now just need a victory over Poland on Tuesday to go through automatically but a draw will let in Ukraine, which beat the Poles 1-0 and have an easy match against San Marino left.
"It is only a half-done job, but it is nice to know whatever happens we will not be out," said England coach Roy Hodgson, whose team can't finish lower than second place.
The scenario is easier for Russia after its 4-0 win in Luxembourg, which left Fabio Capello's team three points ahead of Portugal and needing only a draw in Azerbaijan to guarantee first place.
Portugal conceded a goal to Eden Ben Basat with five minutes left to draw 1-1 at home to Israel and virtually ensure it will be in next month's two-legged playoffs, which feature the top eight runners-up.
Helped by two goals by Edin Dzeko, Group G leader Bosnia-Herzegovina beat Liechtenstein 4-1 at home and can qualify automatically for its first major tournament with a win at Lithuania on Tuesday. Greece defeated Slovakia 1-0 and is level on points with the Bosnians, but has a vastly inferior goal difference.
Elsewhere, Sweden joined Croatia in the playoffs after securing second place in Germany's group with a 2-1 home victory over Austria, with Zlatan Ibrahimovic grabbing a late winner. They are the only two countries definitely in the two-legged playoffs, which will played on Nov. 15 and 19.
Italy, which qualified along with the Dutch last month, equalized in injury time to draw 2-2 at Denmark and leave Bulgaria second on goal difference in Group B despite a 2-1 loss in Armenia.
Iceland stayed second behind Switzerland after overcoming Cyprus 2-0, while Turkey and Romania won away games on Friday to stay tied on points behind the Netherlands with one match remaining.
The Turks have the edge on goal difference but finish off against the Dutch, who showed they are in no mood to relax by ripping apart Hungary in Amsterdam.
Van Persie scored twice before half time and seven minutes into the second half to go one goal ahead of Patrick Kluivert in the all-time list.
"Records are made to be broken ... I'm happy for him," said Kluivert, who is now one of Netherlands coach Louis van Gaal's assistants.
Thirteen of the 32 spots at the World Cup are now set. The United States, Argentina, Australia, Costa Rica, Iran, Japan and South Korea had also already qualified before Friday, and Brazil gets an automatic berth as host.
Colombia and Chile were in position to advance later Friday.
