Shamsi, the world no. 1 ranked T20I bowler in ICC rankings, will be joining the Royals squad as a replacement for Australian pacer Andrew Tye.
The Indian members of the team along with the team management and support staff are amongst the first ones to leave for UAE on Friday.
Malan, who is the world's top-ranked T20 batsman, made a fine comeback in Test cricket after three years with a splendid 70 in England first innings against India.
The 36-year-old Karthik has aggregated 123 runs in seven matches in the first leg of the tournament.
Southee, 32, has previously played for Chennai Super Kings, Mumbai Indians, and Royal Challengers Bangalore in the lucrative T20 league.
Punjab Kings confirmed the signing of England spinner Adil Rashid for the 2021 edition of the Indian Premier League.
The star all-rounders of Mumbai Indians have joined the team camp in Abu Dhabi ahead of the second leg of IPL 2021.
The uncapped left-arm quick has featured in 38 T20 matches and has taken 44 wickets with a bowling average of 20.06.
Australian pacer Andrew Tye, who had left for home amid the COVID-19 pandemic during the first phase of the IPL, said he won't be available for the remainder of the season.
Snapped by RCB for a whopping 15 crores in the auction, Jamieson has scalped nine wickets and made 56 runs with the bat in seven matches of IPL 2021.
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