The Mexican driver had hoped to return after spending seven days in quarantine, but his Racing Point team said Friday morning he had tested positive.
Perez became the first Formula One driver to test positive for coronavirus, and it had been unclear whether he would be available to drive after the period of quarantine was extended to 10 days.
Bottas played a key role in the team's success in the Constructors' Championship over the past three seasons and finished runner-up in the Drivers' Championship in 2019.
Perez was diagnosed with COVID-19 last week that saw him miss the British Grand Prix in Silverstone.
The championship leader's record-extending seventh Silverstone win saw him finish six seconds ahead of Red Bull's Max Verstappen
Lewis Hamilton needs five more wins to equal Michael Schumacher’s Formula One record of 91 GP wins.
Stroll finished fourth at the Hungarian GP two weeks ago for Racing Point, which uses Mercedes engines and has been showing good pace this season.
Sergio Perez believes he caught the virus when he travelled to Mexico between the Hungarian and British races to visit his mother after she had an accident.
The race on Sunday will be the fourth in the pandemic-affected season that should have begun in March.
The revamped Formula 1 season calendar has so far seen three races being completed, all of them were held behind closed doors and the same fate now awaits the Monza GP.
Ferrari has once again got off to a difficult start this campaign as they currently find themselves at the fifth spot in the constructor's standings.
The Algarve International Circuit in Portimao will host the Portuguese Grand Prix on October 23-25, two weeks after the Grand Prix at Germany's Nuerburgring.
Hamilton and others, such as his Mercedes teammate Valtteri Bottas and Ferrari's Sebastian Vettel, took a knee while others appeared to be hurriedly arriving late and not even in position
The British driver's 86th GP win moved him just five behind the German great Schumacher's F1 record of 91.
It was Hamilton’s second straight pole this season and record-extending 90th of his Formula One career.
Championship leader Bottas was .042 seconds ahead of the Formula One champion in overcast conditions on the Hungaroring track.
Vettel was .272 seconds ahead of Mercedes driver Valtteri Bottas and 1.32 clear of McLaren's Carlos Sainz Jr. as it rained throughout the afternoon on the Hungaroring track.
Canadian billionaire Lawrence Stroll, who owns Racing Point, has reportedly offered Vettel a contract.
Lewis Hamilton won the Styrian GP on Sunday, reaching the second spot in the drivers' standings.
It's 52 years since American sprinters Tommie Smith and John Carlos introduced that powerfully defiant gesture to a worldwide TV audience when standing on the podium during their medal ceremony at the 1968 Olympics in Mexico City.
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