Ajax overpowered Tottenham at the start of their Champions League semi-final on Tuesday but could only return with a 1-0 lead from London.
The Netherlands center back collected the Professional Footballers' Association award at a ceremony in London on Sunday. His Liverpool teammate, Mohamed Salah, won the accolade last season.
The draw was a major blow for Manchester United's hopes of Champions League qualification.
The defending champions will retain the title if they win their final two games, at home to Leicester and away to Brighton.
Lionel Messi came off the bench and scored the goal that clinched the La Liga crown for Barcelona.
This is the second time the federation has nominated Gurpreet Singh Sandhu and Jeje Lalpekhlua.
Manchester City defeated Manchester United 2-0 and returned to the top of the table with three games to go while Wolves handed Arsenal a 3-1 defeat at the Molineux.
The celebrations for a second consecutive league trophy — and eighth in 11 seasons — could even start as early as Wednesday if Atletico Madrid lose at home against fifth-place Valencia.
Chelsea climbed into the final Champions League qualifying spot, one point above fifth-placed Arsenal and three ahead of Manchester United, but has played one game more.
Ronaldo became the first player in history to win league titles in the English Premier League (with United), the Spanish league (Madrid) and Serie A (Juventus).
Liverpool beat Cardiff City 2-0 while Everton humiliated Manchester United 4-0 and Arsenal went down to Crystal Palace 2-3 at home.
Clement Lenglet and Jordi Alba scored a goal in each half at Camp Nou Stadium as Barcelona kept a nine-point lead over Atletico Madrid, which had beaten Eibar earlier in the day.
The league is currently at 24 teams, with FC Cincinnati joining this season. Miami and Nashville, Tennessee, are teed up to start next year and Austin, Texas, will come aboard in 2021.
Chelsea beat Slavia Prague 4-3 on aggregate over the two legs while Arsenal got the better of Napoli 3-0 to make the Europa League last four for the second straight year.
Liverpool, which lost in the final last season, will now face Barcelona, which eliminated Manchester United 4-0 on aggregate on Tuesday.
Tottenham reached to its first European Cup semifinal in 57 years and will play Ajax while City’s quadruple dreams were extinguished.
It is the first time since 2010 that Ronaldo has failed to reach the last four, having won the competition the last three years in a row with Madrid.
Messi scored two early goals to help Barcelona beat United 3-0 on Tuesday and reach the Champions League semifinals for the first time in four seasons.
It was Arsenal's first clean sheet in an away league match this season.
Barcelona were left nine points ahead of second-placed Atletico Madrid, which beat Celta Vigo 2-0.
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