2. Muttiah Muralitharan's 1334 International Wickets
Murali was only 20 when he first bowled for Sri Lanka. He turned a few heads with his unusual style, not to mentioned sparked a few controversies, but it soon proved effective as he baffled batsmen around the world.
Nearly 20 years later, he had 800 Test wickets and 534 one-day international wickets—both records.
For someone to challenge Muralitharan's numbers, they would have to be capable of bowling for long periods of a match, remain injury-free for two decades, and be consistently amongst the best bowlers on the international circuit.
It's conceivable, but they will have to be as freakish as Murali.