The crowd went euphoric as Tendulkar drove down West Indies skipper Darren Sammy for a four through mid-on, that also brought up 150 for India.
As he walked off the ground, Tendulkar raised the bat to acknowledge applause all round.
Earlier, Ojha and Ashwin proved too good for the West Indian batsmen on a pitch that offered sharp turn and bounce.
An early tea was taken when Ojha had Gabriel caught behind for the sixth five-wicket haul of his career.
The West Indies, who went for lunch at 93 for two, lost their eight wickets for a mere 89 runs.
