Pakistan batsman Asif Ali, who was representing his nation against England in the fifth and final ODI on Sunday, was dealt with a huge blow just hours after the match, which Pakistan lost by 54 runs.
Ali's two-year-old daughter Noor Fatima, who was battling stage IV cancer, passed away in a hospital in the United States.
The unfortunate event was confirmed by the Twitter handle of Pakistan Super League (PSL) side Islamabad United.
"ISLU family pays its deepest condolences to @AasifAli2018 on the tragic loss of his daughter. Our thoughts and prayers go out to Asif & his family. Asif is a great example of strength & courage. He is an inspiration to us," the PSL franchise tweeted on Monday.
Islamabad United's coach Dean Jones also sent his condolences to him and his family.
"On behalf of my family and the @IsbUnited players and families… we send our condolences and love to @AasifAli2018 and his family on the passing of his beautiful daughter," Jones tweeted.
Ali is now expected to leave the tour of England to support his family.
Earlier on Sunday, the 27-year-old scored 22 against England after coming in to bat at No.7 in Pakistan's chase of 352.
The hard-hitting Ali featured in every game of the series, scoring two fifties with a career best of 52 in the third ODI in Bristol.
Before leaving for England, he had tweeted that he is taking his daughter to the US for treatment.
"My daughter is fighting the stage IV cancer and we are taking her to US for her treatment. A big shout out to @usembislamabad and @USCGLahore for issuing the visa to us within an hour. Special thanks to Mike, Elizabeth, Tanveer & @TalhaAisham Bhai. Keep my princess in your Duas!"