"There are countless matches I wish I could have back, but I am proud of what I was able to accomplish. The journey was nothing short of incredible," Isner said.
After eliminating Andreas Seppi in his opening main draw match, the 20-year-old American qualifier takes out 21st-seeded Isner in the second round with a 6-4, 6-4, 2-6, 6-4 win.
Jordan Thompson pulled off a major upset as he beat John Isner 6-7, 7-6, 6-3 in the second round of New York Open.
Top-seeded Rafael Nadal plays Pablo Carreno Busta, Nick Kyrgios takes on Karen Khachanov and Alexander Zverev plays Fernando Verdasco in other men's third-round matches
Top-seeded Djokovic is on a 24-0 sets winning streak in Asia dating back to last year's Shanghai Masters. He won his inaugural appearance at the Japan Open last week without losing a set.
Roger Federer eased past John Isner in the Miami Open final 6-1, 6-4 to win his 101st career title on Sunday.
There still has not been a repeat champion this year among the men or women.
Roger Federer beat Denis Shapovalov 6-2, 6-4 while John Isner got the better of Felix Auger-Aliassime, 7-6, 7-6 in the semi-finals of Miami Open.
Alexander Zverev defeated John Isner 7-6 6-3 to reach the semi-finals of the ATP Finals for the first time in his career.
The Wimbledon and U.S. Open champion made an impressive start to his campaign for a sixth title by dismissing John Isner 6-4, 6-3.
At the Australian Open and the French Open, players still have to win by two games in the final set in singles matches.
Roger Federer earlier put Team Europe ahead by saving three match points for a 6-7, 7-6, (10-7) victory over John Isner.
Williams reached the quarter-finals at Flushing Meadows for a 10th consecutive appearance by picking her level up after a lull and using 18 aces to beat Kaia Kanepi of Estonia 6-0, 4-6, 6-3.
They had played on and on, through 6 1/2 hours of ho-hum hold after ho-hum hold, during the second-longest match in the history of a tournament that began in 1877.
Isner, a 33-year-old American playing in his 41st major tournament, reached his first Grand Slam semifinal by beating Milos Raonic at the All England Club on Wednesday.
First, Isner beat Joris De Loore 6-3, 6-7 (4), 7-6 (8), 6-4, and Querrey followed with a straight sets victory, beating Ruben Bemelmans 6-1, 7-6 (5), 7-5 to put the US a victory away from reaching the semifinals.
The American had just won the biggest title of his 14-year career, holding every service game and rallying past Alexander Zverev in the finals.
Dominating with his serve and aggressive baseline strokes, the 6-foot-10 Isner ended a 15-match winning streak for del Potro, who won Indian Wells two weeks ago by beating Roger Federer in the final.
Del Potro will play 20th-seeded Milos Raonic for a semifinal berth whereas Isner will face Hyeon Chung.
Krajinovic plays for his first career title against 16th-seeded American Jack Sock, who comfortably beat home favourite Julien Benneteau 7-5, 6-2 in the other semi-final.
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