The Karachi-born Zardari, 58, who assumed the Pakistan president's office Sep 9, 2008, will be replaced by Mamnoon Hussain.
Zardari said Saturday that for him strengthening his Pakistan Peoples Party (PPP) was the most important task than anything else.
He had to quit the PPP's chairmanship on court orders five months ago.
To a question that if he learnt any lessons during his term in imprisonment for corruption, the outgoing president said: "I learnt patience during my 11-year solitary confinement as jail starts to test your nerves after two initial years in detention."