The destruction of the minaret - which dated to 1090 and was the oldest surviving part of the Umayyad Mosque - brought outrage and grief.
"What is happening is a big shame," said Imad a-Khal, a 59-year-old Christian businessman in Aleppo. "Thousands of tourists used to visit this site. Every day is a black day for Syrians."
The main Western-backed opposition group, the Syrian National Coalition, accused the government of intentionally committing "a crime against civilization and humanity" by destroying the minaret.
"The regime has done all it can to tear apart the Syrian social fabric," the Coalition said in a statement. "By its killings and destruction of heritage, it is planting bitterness in the hearts of the people that will be difficult to erase for a long time to come."
There were conflicting accounts about what leveled the minaret, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the mosque's tiled courtyard.