Today's strike was also the first since the one that killed Tehrik-e-Taliban Pakistan chief Hakimullah Mehsud on November 1.
Senior leaders, including Interior Minister Chaudhry Nisar Ali Khan, had accused the US of attempting to “sabotage” talks with the Taliban by targeting Mehsud.
Pakistan Tehrik-e-Insaf, an opposition party led by former cricketer Imran Khan, described the drone attack as a “declaration of war” by the US.
The party, which will hold a sit-in on Saturday to block NATO supply trucks going though Khyber-Pakhtunkhwa province which it rules, said the time had come for Pakistan to take tough action.
“This was a declaration of war against the people of Pakistan by the US,” party spokesperson Shireen Mazari said.