Powell also expressed optimism that the relationship between India and the US will play a central role in global affairs in the decades to come.
"It has become fashionable for 'pundits' to claim that the India-US relationship has fallen into the doldru. I must disagree. A relationship that is strengthening and deepening may not draw splashy headlines, but it is not headlines that should define us. Instead, I look at concrete examples of what we have accomplished," she said.
Giving examples of cooperation on "strategic issues as never before", Powell said India and US have initiated a series of regional dialogues including US-India-Afghanistan bilateral and trilateral meetings and a separate trilateral with Japan.
"Our governments formalised bilateral cooperative efforts in off-grid energy access, nuclear safety, ultra-efficient space cooling, and shale gas development...We exchange information regularly on issues of security concern that makes us safer every day in India, in the United States, and in the world.
"Our militaries train and conduct exercises together in a way that would have been unimaginable just a few years ago," Powell added.
The Defence Trade and Technology Initiative (DTTI) between the two countries has opened a vista where together "we could manufacture more and better defence articles" together, she said.