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Although Covid-19 has primarily been a respiratory disease, it has significantly affected people's other organs including the gut. Researchers from the King's College London observed that the system that would normally regulate the composition of the microbial communities - otherwise known as Peyer's Patches - were severely disrupted in severe Covid-19.
This was irrespective of whether there was evidence of virus present in the gut or not. While severe Covid-19 can lead to breathing problems and high fever, some patients can experience diarrhoea, nausea and vomiting, which suggests involvement of the gastrointestinal tract.
"This study shows that in severe Covid-19, this key component of the immune system is disrupted, whether the intestine itself is infected with SARS-CoV-2 or not," said Professor Jo Spencer, from King's College London.
"This would likely contribute to the disturbances in intestinal microbial populations in Covid-19 reported by others," Spencer added.
The study, published in the journal Frontiers in Immunology, looked at samples of gastrointestinal tract from patients who died after being diagnosed with Covid-19 during the first wave of the pandemic.
Observations of the samples found the structure and cellularity in Peyer's Patches - a grouping of lymphoid follicles that lines the small intestines - had been altered independent of the local levels of the virus.
This included depletion of the germinal centres, which normally propagate antibody producing cells, in patients who died with Covid.
The resulting poor local immunity could lead to a reduction in microbial diversity, known as dysbiosis.
Lymphoid tissue in the gut normally maintains healthy intestinal microbial populations which are essential for good health.
Researchers also noted that the findings suggest that oral vaccination may not be effective if the patient is already ill, as the gut immune system is already compromised.
"In the future it will be important to understand factors driving such lymphoid tissue dysregulation in severe inflammatory responses," Spencer said.
