But when that supply dries up, and with his condition worsening, reality hits him hard. He realizes that he needs to take stock of his life, so he crosses the border to Mexico, where an unlicensed American doctor (Griffin Dunne) tells him AZT is poisonous and suggests alternative treatment. The new treatment stabilizes Ron and he feels better. It also gives him the idea of an entrepreneurial opportunity.
So, in order to target a client base of gays and potential HIV patients, he partners with Rayon (Jared Leto) a drug-addicted transsexual who he meets in the hospital. Together, they start the "Dallas Buyers Club" with a $400 enrolment fee.
Ron circumvents FDA regulations by importing unlicensed drugs that he distributed "for free" through the club, which instead charged an "admission fee", a loophole that meant that technically he wasn't selling the medication. The operation was a scam, but the results were impressive.
McConaughey plays Ron Woodroof with deep sincerity. The physical as well as the emotional evolution of the character through the film is incredibly and spectacularly real. He shines as the despicable, selfish, racist, homophobic and equally excels as a caring and a likeable person.