Rao is currently a member of the Executive Council, Senior Vice President and Global Head-Retail, Consumer Packaged Goods, Logistics and Life Sciences.
Yesterday, Subrahmanyam Goparaju, senior vice president and a member of the executive council that frames business strategy, had resigned.
Goparaju, who joined the company in 1998, was also head of Infosys Labs -- the research and innovation division.
Ashok Vemuri, who led the company's operations in the Americas, resigned in August, the same month when Vice President and Financial Services Head for Americas Sudhir Chaturvedi quit.
In the previous month, Infosys Global Sales Head Basab Pradhan left while Stephen R Pratt, the firm's Head of Utilities and Resources for North America, had put in his papers last month.
In September, Infosys Head of BPO sales in Australia Kartik Jayaraman and BPO Head Latin America Humberto Andrade had quit the company.