After a few hours, I got pretty good at getting the machine to follow my orders. As a longtime Xbox user, however, I still found it easier and more intuitive to use the Xbox One's handheld controller, which looks and feels similar to previous Xbox controllers.
You can also navigate the on-screen menus using Xbox SmartGlass, a free app for iOS, Android or Windows 8 devices, including Microsoft's Surface tablet. If you're in the middle of a game, SmartGlass can display additional instructions or the Achievements you've earned. It's far from essential, but it could be interesting to see what developers do with that second screen.