Allrounders Abdul Razzaq and Shoaib Malik, who both made an unimpressive return to the team for the Twenty20s, got another opportunity to strike forms along with struggling Shahid Afridi, Umar Akmal and Nasir Jasmhed.
Cape Town will host the second Twenty20 on Nov. 22 and the first one-day international on Nov. 24. The remaining two ODIs will be played at Port Elizabeth (Nov. 27) and at Centurion (Nov. 30).
It will be the third bilateral one-day series between the two countries this year. Pakistan lost 3-2 against the Proteas in South Africa earlier this year before losing in the UAE. Pakistan is yet to beat South Africa in seven bilateral one-day series.
The just-completed series saw South Africa jump to No. 3 in the world Twenty20 rankings, and Pakistan fall to No. 4.
Squad: Misbah ul Haq (captain ODIs), Mohammad Hafeez (captain T20s), Ahmad Shehzad, Umar Akmal, Asad Shafiq, Umar Amin, Shahid Afridi, Abdul Razzaq, Shoaib Malik, Sohaib Maqsood, Sohail Tanvir, Anwar Ali, Junaid Khan, Saeed Ajmal, Abdul Rehman, Nasir Jamshed, Bilawal Bhatti.