In the same year, Murli Deora was elected to the Rajya Sabha . He served in the Union Cabinet as Petroleum Minister during UPA 1.
He was closely associated with the Bhartiya Vidya Bhavan and the Indian Red Cross Society.
He was also the President of the Mumbai Regional Congress Committee for 22 years from 1981 to 2003.
In the UPA II, Deora retained the portfolio of Petroleum and Natural Gas under Prime Minister Manmohan Singh.
Murli developed cancer and despite all medical reatment his health continued to deteriorate. He continued to be a sitting member of the Rajya Sabha.