Son of Jan Sangh and later BJP leader late Gangadhar Fadnavis, whom his fellow Nagpur politician and former party chief Nitin Gadkari calls his "political guru", Devendra cut his teeth in politics at a young age when he joined Akhil Bhartiya Vidyarthi Parishad, the students wing of RSS, in 1989.
At 22, he became a corporator in the Nagpur civic body and its youngest Mayor in 1997 at the age of 27.
Fadnavis contested his first assembly election in 1999 and won. There was no looking back for the strong proponent of a separate Vidarbha state as he won three subsequent Assembly elections. He currently represents Nagpur South West seat in the House.