The third wave of Coronavirus is almost here! While the new variant 'Omicron' is stated to be slightly less dangerous, but prevention is always better than cure and first step towards the same is boosting our immune system. According to a study conducted by the University of Florida, eight days of intense meditation causes robust activation of the immune system. The study, published in the 'Proceedings of the National Academy of Sciences Journal,' are believed to be the first comprehensive genomic study of how meditation affects the biological processes directly involved in disease development.
While the positive effects of meditation are well documented, far less is known about its molecular and genetic effects, said Vijayendran Chandran, PhD, an assistant professor of paediatrics and neuroscience in the UF College of Medicine.
Chandran's interest in the molecular roots of Inner Engineering actually started with some prodding by his wife -- and a dose of healthy scepticism. Just try it for 48 days, she said. He did so for about 21 minutes a day. "I tried it and it worked really well. I just felt great," Chandran said.
According to Chandran, the increased gene activity among interferon-signalling genes is particularly significant. Interferon proteins rally other parts of the immune system to defend against viruses and several recent studies have shown that interferon signalling is imbalanced in patients with severe COVID-19. Essentially, meditation used a coordinated network of core genes and regulators to unleash a positive effect on the immune system, the researchers found. "This is the first time anyone has shown that meditation can boost your interferon signalling. It demonstrates a way to voluntarily influence the immune system without pharmaceuticals," he said.
The researchers reported that the findings also have potential implications for many immune-related conditions such as COVID-19 and multiple sclerosis. While meditation boosted activity in the 68 interferon-related genes, patients with severe COVID-19 have the opposite problem: a dearth of interferon activity that inhibits virus-fighting. When researchers compared interferon gene activity in the retreat participants and severely ill COVID-19 patients, the differences were stark.
Meditation activated 97 per cent of interferon-response genes, compared with 76 per cent gene activation in mild COVID-19 patients and 31 per cent in severe COVID-19 cases. They also observed the opposite trend for inflammation-signalling genes, where they saw significantly high levels of inflammatory genes in severe COVID-19 patients, compared with mildly ill patients, and no change in inflammatory genes after meditation.
Likewise, meditation produced beneficial gene activity comparable to conventional interferon treatments given to multiple sclerosis patients. Taken together, the findings supported the idea that meditation contributed to potentially improving multiple health conditions, the researchers concluded. While the findings are intriguing, Chandran also said that the beneficial gene-activity effects need further study, including replication in a randomized clinical trial.
It could also be helpful to determine if a less intense meditation regimen in the long term might produce similar beneficial immune-system effects, he said. Research funding was provided by the UF Department of Pediatrics. Collaborators from the Indiana University School of Medicine, the University of Louisville, and the Beth Israel Deaconess Medical Center contributed to the research.
